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BabyPepper

BabyPepper locks your computer so that your baby can safely bang away on your keyboard and mouse.
The screen remains live, so you can keep on watching videos, play music, or talk to somebody over Skype™.

BabyPepper is great for us to talk with grandpa over Skype. The little one can bang away on that keyboard and we don't have to worry about what damage he might have done to the computer." –Sallee

Need to run on a Mac?
Check-out AlphaBaby:
http://alphababy.sourceforge.net/

And here is an implementation of
AlphaBaby for Windows called BabySmash:
http://www.babysmash.com/

We are not affiliated with AlphaBaby and BabySmash—they just seem to be nice products that do similar things.